Clomiphene is a drug used by fertility care physicians to induce maturation and release of an ovum from the ovaries of a female. It is a prescription only drug and needs to be used according to a plan than in a randomized manner. Although the drug is safe in its use, multiple side effects of mild to moderate nature have been reported among its users.
What are the indications to use Clomiphene?
As mentioned earlier, one of the reasons to use Clomiphene is to induce maturation and release of an ovum or an egg from the ovaries. This is necessary when a female fails to get pregnant due to poor ovulation or immature ovum’s that she produce from her ovary. It is also useful in instances where the female does not have regular menstrual cycles. At the same time, it can also be used prior to ‘assisted reproductive techniques’ such as in-vitro fertilization (IVF) in which case the clinicians requires to extract mature eggs from the ovum in order to proceed with the fertilization.
Apart from these uses, Clomiphene has also been used in males in instances where pituitary hormonal deficiencies cause the sperm counts to be low or less motile which can also give rise to fertility problems.
How should Clomiphene be taken?
The drug is available in the tablets form and should be taken according to the prescription given by the physician. Usually, one tablet should be taken each day for about 5 days for a single cycle of Clomiphene. The tablets need to be taken at the same time each day in order to maintain a sustained level of Clomiphene in the blood. Depending on the response to the medications, the clinicians will decide on the number of cycles a female has to undergo in order to be successful.
The timing of its take have to be three to five days after beginning of a new menstrual cycle or else following inducing menses through another drug, in instances of irregular menses. The doctors will decide the timing of its take and will let the patients know. In some instances, Clomiphene intake may also be supplemented by Metformin which is an insulin sensitizing agent that seems to improve the action of Clomiphene in the ovulation process.
Following completing the cycles, the ovulation usually takes place within 5 to 12 days. During this period, the doctors will be observing the ovulation process and depending on the reason for its use, one may have to undergo ultrasound examinations to assess the situation in the ovaries.
What are the side effects of Clomiphene intake?
The side effects associated with Clomiphene use are mostly mild and sometimes could be moderate. Thus, the commonest manifestations would include an enlargement of the ovaries, hot flushes, abdominal or pelvic pain, nausea and vomiting, upset stomach, headache, breast pain…etc. Most of these symptoms will gradually disappear as the treatment continue or will disappear following stopping the drug. However, one should consult the doctor who started the medication in order to obtain further advice. Lastly, it should be remembered that, there is a 10% chance of multiple pregnancies when ovulation is induced by Clomiphene.