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What is Azilect

What is azilect prescribed for?

Azilect is a medication used to alleviate symptoms of Parkinsons disease. Its generic name is Rasagiline. This drug is in the Monoamine Oxidase inhibitor B category. This medication is prescribed alone or with the combination of other anti parkinsons disease drugs.

What is parkinsons disease?

Parkinsons disease is a chronic disorder affecting movements of the body. It is characterized by slowing of movements, resting tremors and muscle stiffness. At the moment it has no cure. But the disease pregression can be slowed and symptoms can be alleviated by taking several anti parkinsons drugs.

Parkinsons disease is caused by selective destruction of dopamine secreting neurons in the substantia nigra and basal ganglia of the human nervous system. What causes this destruction is largely unknown. But once initiated, it cannot be stopped. Drugs used in this disease increase the dopamine levels in above areas and improves symptoms.

How Azilect improves symptoms?

Azilect Irreversibly inhibits mono amine oxidase B enzyme in the neurons. Mono Amine Oxidase enzyme breaks down amines such as dopamine. There are two types of mono amine enzymes. One is MAO A, other is MAO B. MAO A is predominantly found in Gastro intestinal tract and liver. MAO B is predominantly found in the brain. Selective MAO B inhibition causes fewer side effects.

How it is prescribed?

Usually Azilect is prescribed alone in the early part of the disease. Its effectiveness is proven in various randomized double blind clinical trials. Later in the disease, this drug is co prescribed with Levodopa (Sinemet®).

What are the things you should know before taking Azilect?

Some medications should not be used with Azilect. They are Demerol, Ultram, Darvon, Methadose, St. John’s Wort, Flexeril and dextromethorphan. The doctor must know all the medications patient is on before prescribing Azilect. This includes over the counter medications as well. Do not take a new medication without medical advice, while on Azilect.

Tell your doctor if you have,

* High blood pressure

* Liver disease

* Kidney disease

If you are pregnant or breast feeding, then inform that to the doctor as well.

General advice

Azilect is available as tablets. Take the medication as prescribed by the doctor. Do not share this medication with anyone else. Do not take alcoholic beverages, while on Azilect. Keep this medication out of reach to children.

What are the dangerous side effects?

Azilect can increase the blood pressure to dangerous levels. So if you get severe headache, anxiety, confusion, blurred vision, buzzing in your ears, chest pain, shortness of breath, uneven heartbeats and seizure then seek medical advice.

Sources

BNF