Accuretic is a combination of two anti hypertensives, Hydrochlorothiazide and Quinapril. It is a prescription only medication. Hydrochlorothiazide is a thiazide type diuretic. It increases urine production and eliminate excess water and salts from the body. Quinapril is an ACE inhibitor. This drug widens the arteriolar lumen and reduces blood pressure. Combination of these drugs reduces blood pressure more effectively than a single agent alone.
This drug combination is prescribed in heart failure, high blood pressure and in diabetes kidney damage.
Doctors usually start Accuretic on hypertensive patients who are not responding to a single drug alone or for patients who have heart failure or hypertension with diabetes mellitus. Before starting this medication doctor should know your complete medical history, including over the counter medication patient is on.
If the patient have kidney disease called renal artery stenosis, the doctor will not start Accuretic. If the patient have liver problems, doctor should know that as well. Liver diseases can cause problems with Hydrochlorothiazide part of this drug. If the patient have a heart disease called aortic or mitral valve stenosis doctor may not prescribe this medication. Conditions like hypertrophic cardiomyopathy can cause problems with this drug as well.
This medication should be taken as a whole with full glass of water and it should not be crushed to minimize side effects. This medication can be taken with or without meals.
If the patient is pregnant or nursing, doctor will not start Accuretic. Taking Accuretic in pregnancy can harm the unborn baby. Even though this drug is not present in breast milk in significant amounts, manufacturer advices to avoid during breast feeding.
During therapy doctor will do several blood tests to see whether your body electrolytes are in normal range. Serum potassium levels can go up with this medication.
Most troublesome side effect is the dry cough. Dizziness and low blood pressure can occur commonly. Gastro intestinal disturbances like nausea and vomiting are also common side effects. This medication can increase urine output. So it is convenient to take it in the morning. This drug can alter plasma lipid levels as well.
This medication is a potent antihypertensive, so patients can get faintishness especially in the first few days of the treatment. Less common side effects are blood disorders like reduced white cell counts, pancreatitis, cardiac rhythm abnormalities, headache and dizziness.
Few patients may get shortness of breath and muscle/joint pains with this medication. This medication is known to cause upper respiratory tract infections.
Very few patients can get an allergic reactions to this medication. Sometimes it can lead to an anaphylactic shock. This is characterized by wide spread hives, low blood pressure, shortness of breath and pallor. Patient should seek immediate medical help if he/she gets this problem.
British National Formulary